University Distinguished Professor
Department of Microbiology, Immunology, and Pathology
College of Veterinary Medicine and Biomedical Sciences
Colorado State University
Fort Collins CO 80523-1619 USA
Office: 970-491-7587
Fax: 970-491-0523
Cell: 970-218-7672
E-mail: edward.hoover@colostate.edu
Dr. Hoover's laboratory focuses on the pathogenesis and intervention for retrovirus and prion infections--in particular the feline and simian immunodeficiency viruses (FIV, SIV), the feline leukemia virus (FeLV), and the prion disease chronic wasting disease (CWD) of deer and elk. These agents are causes of fatal disease in animals and models for human diseases-i.e. HIV infection/AIDS, leukemia, bovine spongiform encephalopathy (mad cow disease, BSE), and Creutzfeld-Jakob disease. Research in the Hoover laboratory led to development of the most widely used vaccine against FeLV infection in cats. Current work focuses on: (1) the mechanisms whereby FIV crosses the mucous membranes and infects initial target cells, (2) the role of early innate and acquired immunity in containing or failing to contain FIV infection, (3) transmission, shedding and detection of the CWD prion in deer, transgenic mice, and other species, and (4) experimental vaccination for prion infections.
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